Frequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in Uzbekistan

P-glycoprotein (P-gp) is encoded by the MDR1 gene and involved in pharmacokinetics of drugs. The best-known polymorphisms are 1236C>T, 3435C>T, 2677G>T/A, which associated with protein folding, changes mRNA levels, drug pharmacokinetics. aim this study was to identify frequency distribution functional C1236T, C3435T, G2677T/A their haplotypes Uzbekistan. For research, peripheral blood samples were obtained from 218 apparently healthy people genotyped Polymerase Chain Reaction (PCR) restriction analysis (RFLP). results genotyping C1236T variant 21 volunteers showed that T allele 58.7%, C 41.3% (P = 0.377891). occurrence alleles for polymorphism 2677G>T/A as follows: G, 94.5%; A, 5.5% (P>0.005). 43% 57% 0.561084). This also evaluated simultaneous presence gene. most frequently occurring combination genotypes CT/GG/CT (26.1%) TT/GG/TT (17.4%). common haplotype CGC, representing appearance all wild-type tested SNPs, 6.4% (n 14) a normal genotype. However, polymorphic nucleotides (TAT) not found. research made it possible establish frequencies C3435T among our CT TT both higher than CC Although insufficient assess Uzbekistan residents, further will be focused on these wide range confirm reliability results.